Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities

Immunoassays in microfluidic systems.

Immunoassays have greatly benefited from miniaturization in microfluidic systems. This review, which summarizes developments in microfluidics-based immunoassays since 2000, includes four sections, focusing on the configurations of immunoassays that have been implemented in microfluidics, the main fluid handling modalities that have been used for microfluidic immunoassays, multiplexed immunoassa...

Microfluidic Systems Integrated Microfluidic Systems**

Microfluidic systems use networks of channels thinner than a human hair to manipulate nanoliter volumes of reagents. The goal of microfluidics is challenging: to integrate, on a chip smaller than a credit card, all operations normally performed in a chemical or medical laboratory. Synthesis, purification, analysis, and diagnostics would be performed by such a “lab on a chip” rapidly, economical...

Microfluidic Immunoassays

Soft microfluidic assemblies of sensors, circuits, and radios for the skin.

When mounted on the skin, modern sensors, circuits, radios, and power supply systems have the potential to provide clinical-quality health monitoring capabilities for continuous use, beyond the confines of traditional hospital or laboratory facilities. The most well-developed component technologies are, however, broadly available only in hard, planar formats. As a result, existing options in sy...

Skin-interfaced systems for sweat collection and analytics

Recent interdisciplinary advances in materials, mechanics, and microsystem designs for biocompatible electronics, soft microfluidics, and electrochemical biosensors establish the foundations for emerging classes of thin, skin-interfaced platforms capable of capturing, storing, and performing quantitative, spatiotemporal measurements of sweat chemistry, instantaneous local sweat rate, and total ...